Progenn was originally developed by Dr. Domenick Masiello, D.O. in 1996 for his personal practice. After positive results in multiple patients, Dr. Masiello patented his homeopathic formula in 1998 and trademarked the name, Progenn. Progenn was sold through the Yellowflower Company until 2006, when Standard Homeopathic Company purchased the product and all related assets and materials.

Dr. Masiello is board certified in Homeopathy, Family Practice and Osteopathic Manipulation. He practices in New York City and Ridgefield, CT.